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Medicine balls are weighted fitness balls. Usually made of rubber or leather and filled with sand or other materials, medicine balls can increase the difficulty of most workouts. These fitness balls can be used for strength training or explosive training and can also be used during rehabilitation. Medicine balls usually weigh between 2 and 50 pounds and can be used in place of dumbbells for certain workouts. You can also hold the medicine ball(s) during regular squats, sit-ups, overhead presses, chest presses, abdominal exercises, or lunges for a more intense workout.